Thyroid-gut axis: the relationship between gut microbiota and hypothyroidism
DOI:
https://doi.org/10.18378/rebes.v15i3.11365Palavras-chave:
Gut microbiota, Hypothyroidism, Dysbiosis, Metabolism, NutritionResumo
Objective: Systematically review recent scientific literature regarding the relationship between gut microbiota and hypothyroidism. Methods: A bibliographic search was conducted in PubMed and Frontiers databases using descriptors "gut microbiota", "hypothyroidism", "thyroid diseases", and "Mendelian randomization". Articles from the last two years directly addressing this relationship were included. Results: Eight studies were selected, demonstrating a significant association between gut microbiota alterations and the development or worsening of hypothyroidism. Reductions in short-chain fatty acid-producing bacteria, specific metabolites directly affecting thyroid function, and causal associations confirmed by robust studies were observed. Conclusion: There is a significant interaction between gut microbiota and hypothyroidism, indicating that dietary interventions targeting microbiota modulation could positively influence thyroid health, thus warranting further clinical research.
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IANG, W. et al. The relationships between the gut microbiota and its metabolites with thyroid diseases. Frontiers in Endocrinology, v. 13, p. 943408, 2022. Disponível em: https://doi.org/10.3389/fendo.2022.943408. Acesso em: 7 maio 2025.
LIU, X. et al. Investigating causal associations among gut microbiota, metabolites and autoimmune hypothyroidism: a univariable and multivariable Mendelian randomization study. Frontiers in Immunology, v. 14, p. 1213159, 2024. Disponível em: https://doi.org/10.3389/fimmu.2023.1213159. Acesso em: 7 maio 2025.
MENDOZA-LEÓN, M. J. et al. Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases. Frontiers in Endocrinology, v. 14, p. 1192216, 2023. Disponível em: https://doi.org/10.3389/fendo.2023.1192216. Acesso em: 7 maio 2025.
SHI, C. et al. Cross-talk between the gut microbiota and hypothyroidism: a bidirectional two-sample Mendelian randomization study. Frontiers in Nutrition, v. 11, p. 1286593, 2024. Disponível em: https://doi.org/10.3389/fnut.2024.1286593. Acesso em: 7 maio 2025.
STRAMAZZO, I. et al. Microbiota and thyroid disease: an updated systematic review. Advances in Experimental Medicine and Biology, v. 1370, p. 125–144, 2023. Disponível em: https://doi.org/10.1007/5584_2023_770. Acesso em: 7 maio 2025.
VIRILI, C. et al. The relationship between thyroid and human-associated microbiota: a systematic review of reviews. Reviews in Endocrine & Metabolic Disorders, v. 25, n. 1, p. 215–237, 2024. Disponível em: https://doi.org/10.1007/s11154-023-09839-9. Acesso em: 7 maio 2025.
XIE, L.; ZHAO, H.; CHEN, W. Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study. Frontiers in Endocrinology, v. 14, p. 1240752, 2023. Disponível em: https://doi.org/10.3389/fendo.2023.1240752. Acesso em: 7 maio 2025.
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Copyright (c) 2025 Joseli Aparecida Braga Mota, Daniela Marin Machado Silveira , Rodrigo Aparecido Silva, Lynea Glasyele Honorato Pereira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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