Potencial fitofarmacêutico e ecossustentável da Aloe vera na cicatrização

Abstract

The use of medicinal plants integrates transgenerational ethnoknowledge and serves as a foundation for the development of phytopharmaceutical products under the aegis of sustainability. Among the most prominent species, Aloe vera exhibits socioeconomic, pharmacological, and ecological relevance in wound treatment and the biological inputs industry. To analyze the phytopharmaceutical and eco-sustainable potential of the Aloe vera plant in wound healing, investigating its phytochemical mechanisms, biological efficacy in skin regeneration, and applications from the perspective of sustainable development and environmental conservation. This is an integrative literature review, descriptive in nature with a qualitative approach, utilizing the SciELO, LILACS, and PubMed databases, covering the period from 2016 to 2026. The phytochemical matrix of Aloe vera, rich in polysaccharides (acemannan and glucomannan), acts synergistically across the three stages of wound healing (inflammatory, proliferative, and remodeling). In agribusiness and the pharmaceutical industry, it holds high economic value for semi-arid regions due to its low water footprint and climate resilience, helping to prevent soil degradation. The use of its gel aligns with Green Chemistry principles by replacing synthetic polymers with biodegradable ingredients, although it requires technological rigor for stabilization and aloin removal. The integration of traditional knowledge and biotechnology validates the efficacy of Aloe vera as an ecologically viable and clinically effective active ingredient, and further clinical trials are recommended to standardize sustainable phytopharmaceutical formulations.