Efeitos antioxidantes da própolis
DOI:
https://doi.org/10.18378/rebes.v8i4.6330Palavras-chave:
Saúde, Abelhas, Tratamento.Resumo
Propôs-se revisar e analisar os efeitos antioxidantes da própolis. Foi realizada uma Revisão Integrativa, em que o levantamento bibliográfico realizado pela base de dados Biblioteca Virtual em Saúde. Utilizaram-se, assim, os Descritores Controlados em Ciências da Saúde em inglês “antioxidant effect” e propolis, reunindo um total de 24 artigos depois de aplicados os critérios de inclusão e exclusão. Os resultados indicam que os compostos da própolis, principalmente o éster fenólico do ácido caféico (CAPE) podem ser usados para aliviar muitas patologias como doença de Chagas, doenças cardíacas e renais, melhorar a atividade citotóxica, eliminar os radicais e consequentemente favorecer potencial terapêutico para uso na prevenção e tratamento de doenças associadas ao estresse oxidativo e mediadas por inflamação. Muitos são os efeitos antioxidantes da própolis e sua atuação na prevenção de doenças, o que ressalta a importância de incentivar o uso desse poderoso produto natural, incorporando-o no dia-a-dia das pessoas.
Downloads
Referências
ALENCAR, S.M. Própolis vermelha do Brasil: produção, composição e atividade biológica. Piracicaba: USP-ESALQ, 2009.
AKYOL, S. et al. Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review. The Scientific World Journal, n. 56191, p.1-16, 2014.
AKYOL, S. et al. Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review). Molecular Medicine Reports, v.12, n.3, p.3231-3235, 2015.
BELMIRO, M. S.; OKI Y.; FERNANDES G. W. O presente das abelhas. Revista Planeta, n. 463, 2011. Disponível em: <https://www.revistaplaneta.com.br/o-presente-das-abelhas-propolis/>. Acesso em: 23 out. 2018.
BONAMIGO, T. et al. Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome. Plos One, v.12, n.9, p.1-19, 2017.
BONAMIGO, T. et al. Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis andMelipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity, n. 1038153 p.1-12, 2017.
BRIDI, R. et al. International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their Polyphenolic-Related In Vitro Activities. Journal of Food Science, v.80, n.6, p.1188-1195, 2015.
CAMPOS, J. F. et al. Antimicrobial, antioxidant and cytotoxic activities of propolis 4 from Melipona orbignyi (Hymenoptera, Apidae). Food and Chemical Toxicology, v.65, p.374-380, 2014.
COSTA, L. A. et al. Genetic Determinants of Dietary Antioxidant Status. Progress in Molecular Biology and Translational Science, v. 108, p. 179-200, 2012.
DEVASAGAYAM , T. P. et al. Free radicals and antioxidants in human health: current status and future prospects. Journal of the Association of Physicians of India, v.52, p.794-804, 2004.
FANG, Y. et al. Ethanol extract of propolis protects endothelial cells from oxidized low density lipoprotein-induced injury by inhibiting lectin-like oxidized low density lipoprotein receptor-1-mediated oxidative stress. Experimental Biology and Medicine, v.239, n.12, p. 1678-1687, 2014.
FREIRES, I. A.; ALENCAR, S. M.; ROSALEN, P. L. A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases. European Journal of Medicinal Chemistry, v.110, p. 267-279, 2016.
FROZZA, C. O. S. et al. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red própolis. Food and Chemical Toxicology, v.52, p. 137-142, 2013.
KASIOTIS, K. M. et al. Revisiting Greek Propolis: Chromatographic Analysis and Antioxidant Activity Study. Plos One, v.12, n.1, p.1-27, 2017.
LISBOA, S.; RECKZIEGEL T. Própolis faz bem mesmo? Veja o que a ciência tem a dizer. Revista saúde, 2017. Disponível em: <https://saude.abril.com.br/alimentacao/o-que-e-propolis-beneficios/>. Acesso em: 23 out. 2018.
MAVRI, A. et al. Chemical properties and antioxidant and antimicrobial activities of Slovenian propolis. Chemistry & Biodiversity, v.9, n.8, p.1545-1558, 2012.
MELO, A. A. M. et al. Capacidade antioxidante da própolis. Pesquisa Agropecuária Tropical, v. 44, n. 3, p. 341-348, 2014.
MENDONÇA, I. C. G. et al. Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells. BioMed Central BMC Complementary and Alternative Medicine, v.15, n.357, p.1-12, 2015.
MIYAZAKI, Y. et al. Ethanol extract of Brazilian propolis ameliorates cognitive dysfunction and suppressed protein aggregations caused by hyperhomocysteinemia. Bioscience, Biotechnology and Biochemistry, v. 79, n. 11, p.1884–1889, 2015.
MURTAZA, G. et al. Caffeic Acid Phenethyl Ester and Therapeutic Potentials. BioMed Research International, n. 145342, p. 1-9, 2014
NI, J. et al. The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity, n. 7984327, p. 1-13, 2017.
SAITO, Y. et al. Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation. BioMed Central BMC Complementary and Alternative Medicine, v.15, n.421, p.1-8, 2015.
SILVA, B. B. et al. Composition and botanical origin of red propolis, a new type of Brazilian propolis. Evidence Based Complementary and Alternative Medicine, v.5, p.313-316, 2007.
SILVA, R. P. D. et al. Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. Plos One, v.12, n.3, p.1-18, 2017.
SILVA, V. et al. Antioxidant Activity of Uruguayan Propolis. In Vitro and Cellular Assays. Journal Of Agricultural And Food Chemistry, v.59, n.12, p.6430-6437, 2011.
SONG, J-J et al. Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells. International Journal of Pediatric Otorhinolaryngology, v.76, n.5, p.675-679, 2012.
THIRUGNANASAMPANDAN, R.; RAVEENDRAN, S. B.; JAYAKUMAR, R. Analysis of chemical composition and bioactive property evaluation of Indian propolis. Asian Pacific Journal of Tropical Biomedicine, v.2, n.8, p. 651-654, 2012.
TOLBA, M. F. et al. Caffeic Acid Phenethyl Ester: A Review of Its Antioxidant Activity, Protective Effects against Ischemia-reperfusion Injury and Drug Adverse Reactions. Critical Reviews in Food Science and Nutrition, v. 56, n.13, p. 2183-2190, 2014.
TYSZKA-CZOCHARA, M. et al. Zinc and Propolis Reduces Cytotoxicity and Proliferation in Skin Fibroblast Cell Culture: Total Polyphenol Content and Antioxidant Capacity of Propolis. Biological Trace Element Research, v. 160, n.1, p.123-131, 2014
ZHANG, P. et al. Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives. Molecules, v. 19, n.10, p. 16458-16476, 2014.
ŽIŽIĆ, J. B. et al. Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. Journal Of The Science Of Food And Agriculture, v.93, n.12, p.3001-3009, 2013.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Termo de cess
1.png)
milenanunes@fiponline.edu.br 
+55 83 988784633 (Milena Sousa)